Small Pellets - Cracking Point

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Cracking force, distance to first crack, initial gradient

Abstract

This study describes a method for cracking small pellets. Small pellets are often crushed but the sensitivity of the TA can analyze the initial crack. A pharmaceutical manufacturer was making a series of small pellets with a diameter of 0.2 mm with a very powerful active ingredient encapsulated within the shell. It was also making pellets of different outside hardnesses and it was necessary for them to measure the point at which the pellet cracked, not crushed as is the results with a traditional pill hardness tester. A TA.XTPlus texture Analyzer with a 30 kg capacity and 1 g sensitivity was used for the test.