Disintegration of Tablets

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disintegration rate

Abstract

Certain tablets must be strong enough to survive manufacturing and shipping, and yet friable enough to instantly release their pharmaceutical ingredients once they are placed in the mouth or ingested. Traditional disintegration tests do not always distinguish among tablets which release their active ingredients very quickly, and traditional tests may not always reflect the real in vivo disintegration of tablets. In order to test disintegration, a tablet was attached to a cylinder probe. A moderate amount of force was applied while the tablet was submerged in a beaker of water for 60 seconds. It was found that the TA.XT2i Texture Analyzer more accurately measures disintegration rates of tablets than traditional tests.