Application Studies / Small Pellets - Cracking Point

Small Pellets - Cracking Point

Industry:

Pharmaceutical

Attributes measured:

brittleness

hardness

firmness

cracking force

distance to first crack

initial gradient

Background

This study describes a method for cracking small pellets. Small pellets are often crushed but the sensitivity of the TA can analyze the initial crack. A pharmaceutical manufacturer was making a series of small pellets with a diameter of 0.2 mm with a very powerful active ingredient encapsulated within the shell. It was also making pellets of different outside hardnesses and it was necessary for them to measure the point at which the pellet cracked, not crushed as is the results with a traditional pill hardness tester. A TA.XTPlus texture Analyzer with a 30 kg capacity and 1 g sensitivity was used for the test.

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