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syringability, syringe force, syringe friction, syringe stiction
This study describes a method for measuring the force is required to expel material from a syringe. The TA.XTPlus was used to easily generate results that were extremely repeatable and differentiating. The ease with which injectable pharmaceuticals flow out a syringe and through a needle determines how easily the preparation can be administered, impacts patient comfort during injection and affects how the material is received when deposited under the skin. This “syringability” can easily be measured by pushing down on a filled syringe piston with the TA.XTPlus Texture Analyzer and recording its resistance to compression. In this study the force required to express three liquids from a 3 cc disposable syringe out a 22 gauge needle was precisely quantified and compared.